Snail2 controls mesodermal BMP/Wnt induction of neural crest
نویسندگان
چکیده
منابع مشابه
Snail2 controls mesodermal BMP/Wnt induction of neural crest.
The neural crest is an induced tissue that is unique to vertebrates. In the clawed frog Xenopus laevis, neural crest induction depends on signals secreted from the prospective dorsolateral mesodermal zone during gastrulation. The transcription factors Snail2 (Slug), Snail1 and Twist1 are expressed in this region. It is known that Snail2 and Twist1 are required for both mesoderm formation and ne...
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Neural crest cells form within the neural tube and then undergo an epithelial to mesenchymal transition (EMT) to initiate migration to distant locations. The transcriptional repressor Snail2 has been implicated in neural crest EMT via an as of yet unknown mechanism. We report that the adaptor protein PHD12 is highly expressed before neural crest EMT. At cranial levels, loss of PHD12 phenocopies...
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ژورنال
عنوان ژورنال: Development
سال: 2011
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.064394